I went bioactive when both of my snakes were about a year old and it's been great. Mine have not tried to eat the isopods or springtails. I use zebra isopods so they're pretty big. I don't think exoskeletons would be an issue if snakes are digesting bones on a regular basis.

I only keep young snakes on paper towel to help monitor their droppings and feeding. I think you're safe to go bioactive once you know your snake is healthy.

Good luck!