I know it's tough with giving the injections and the snake will certainly not be thrilled about it. Interestingly, Cee Cee calmed down after the first couple and seemed to understand that I was helping her and that it was making her better. I asked the vet about oral meds when both Cee Cee and Sammy were sick...he said that unless I could be certain that I could get the meds in the snake's mouth...injections were better. I know with my snakes, getting an oral med in the mouth would not go well...guess it depends on the snake.