Most of my Nerodia fasciata will try to bite, but with gloves it's not much of a problem. A few Thamnophis will strike (male Thamnophis melanogaster canescens. male Thamnophis sirtalis parietalis, female Thamnophis atratus stratus); it doesn't bother me. Snake room cools down at night (60*F); I can handle my snakes best in the morning when they're not so active.